(SLE)
ADEBRELIMAB(INNC)
IMMUNOGLOBULIN G4-KAPPA, ANTI-[HOMO SAPIENS CD274 (PROGRAMMED DEATH LIGAND 1, PDL1, PD-L1, B7 HOMOLOG 1, B7H1)], MONOCLONAL ANTIBODY; GAMMA4 HEAVY CHAIN (1-446) [VH (HOMO SAPIENS IGHV1-46*01 (89.8%) -(IGHD) -IGHJ4*01 (93.3%)) CDR-IMGT [8.8.12] (26-33.51-58.97-108) (1-119) - HOMO SAPIENS IGHG4*01, G4V5 H P10, G4V4 CH2 A1.3, A1.2 (CH1 (120-217), HINGE 1-12 S10>P (227) (218- 229), CH2 F1.3>A (233), L1.2>A (234) (230-339), CH3 (340-444), CHS (445-446)) (120-446)], (133-218')- DISULFIDE WITH KAPPA LIGHT CHAIN (1'-218') [V-KAPPA (MUS MUSCULUS IGKV3-5*01 (84.8%) -IGKJ2*03 (90.9%)/HOMO SAPIENS IGKV4-1*01 (68.3%) -IGKJ2*01 (100%)) CDR-IMGT [10.3.9] (27-36.54-56.93-101) (1'- 111') -HOMO SAPIENS IGKC*01 (100%) KM3 A45.1 (157), V101 (195) (112'-218')]; DIMER (225-225":228-228")-BISDISULFIDE, PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM ALFA. PROPOSED INN: LIST 122(WHO)
ADEBRELIMABUM(INN)