(INNE)
AUTOLOGOUS CD4+ AND CD8+ T CELLS OBTAINED BY LEUKAPHERESIS, TRANSDUCED WITH AN HIV-DERIVED SELFINACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ENHANCED-AFFINITY T CELL RECEPTOR (TCR) SPECIFIC FOR THE HUMAN MELANOMA ANTIGEN A4 (MAGE FAMILY MEMBER A4, ANTIGEN MAGE A4) HLA-A*02 PEPTIDE DRIVEN BY THE ELONGATION FACTOR 1 ALPHA (EF1ALPHA) PROMOTER. CELLS EXPRESS LYMPHONODE-HOMING MARKERS CCR7 AND CD62L, CD45 ISOFORMS CD45RA AND CD45R0, COSTIMULATORY MARKERS CD27 AND CD28, IL-7 RECEPTOR CD127, AND CHEMOKINE RECEPTOR CXCR3. CELLS SECRETE INTERLEUKIN 2 (IL-2), TUMOR NECROSIS FACTOR (TNF-ALPHA, TNFALPHA), INTERFERON GAMMA (INTERFERON GAMMA, IFN-GAMMA), GRANZYME, INTERLEUKIN 4 (IL-4), INTERLEUKIN 13 (IL-13) AND INTERLEUKIN 17 (IL-17) UPON ACTIVATION.(WHO)
AFAMITRESGENUM AUTOLEUCELUM(INN)