(INNC)
AUTOLOGOUS T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS, TRANSDUCED WITH A SELF-INACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR, ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19, PLUS TWO SHORT HAIRPIN RNAS (SHRNA) DIRECTED AGAINST TWO IMMUNE CHECKPOINT REGULATORS, PROGRAMMED CELL DEATH PROTEIN 1 (PD-1) AND T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS (TIGIT). THE EXPRESSED TRANSGENE COMPRISES A CD8ALPHA LEADER SEQUENCE, A MURINE ANTI-CD19 SINGLE CHAIN VARIABLE FRAGMENT (SCFV) (DERIVED FROM THE MOUSE HYBRIDOMA FMC63), A CD8ALPHA HINGE AND TRANSMEMBRANE REGION, AND A 4-1BB (CD137) AND CD3ZETA (CD247) INTRACELLULAR SIGNALLING DOMAIN, AND IS UNDER CONTROL OF THE ELONGATION FACTOR 1 ALPHA (EF1ALPHA) PROMOTER.; ... PROPOSED INN: LIST 127(WHO)
ANBALCABTAGENUM AUTOLEUCELUM(INN)