(SLE)
AUDENCEL(INNC)
AUTOLOGOUS INTERLEUKIN (IL)-12-SECRETING DENDRITIC CELLS (DCS), LOADED WITH AUTOLOGOUSTUMOUR LYSATE, COMPRISING >70% OF TOTAL IMMUNE CELLS. THE CELLS ARE DIFFERENTIATED FROM AUTOLOGOUS MONOCYTES BY CULTURING IN THE PRESENCE OF INTERLEUKIN (IL)-4 AND GM-CSF (GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR), FOLLOWING WHICH THEY ARE EXPOSED TO THE PATIENT'S TUMOR PROTEIN/TUMOR-ASSOCIATED ANTIGEN (TAA), AND SUBSEQUENTLY TO LIPOPOLYSACCHARIDE (LPS) IN THE PRESENCE OF INTERFERON GAMMA (IFN-GAMMA) TO ENABLE IL-12 SECRETION.(WHOM)
AUDENCELUM(INN)