(SLE)
AUTOGEN CEVUMERAN(INNC)
5'-CAPPED SINGLE-STRANDED MESSENGER RNA (MRNA) CONSTRUCT FOR THE EXPRESSION OF PATIENT-SPECIFIC TUMOUR NEOANTIGENS COMPRISING A 5'-CAP, A 5'-UNTRANSLATED REGION DERIVED FROM HUMAN ALPHA-GLOBIN MRNA, AN OPTIMISED KOZAK SEQUENCE, SEQUENCES ENCODING A SECRETORY SIGNAL PEPTIDE (SEC2.0), TRANSMEMBRANE AND CYTOPLASMIC DOMAINS OF A MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I MOLECULE (MITD), A 3'-UNTRANSLATED REGION (FI) AND A POLY(A)-TAIL; SEQUENCES ENCODING PATIENT SPECIFIC ANTIGENS ARE INSERTED BETWEEN THE SECRETORY SIGNAL PEPTIDE AND THE TRANSMEMBRANE/CYTOPLASMIC ENCODING DOMAINS. PROPOSED INN: LIST 122(WHO)
AUTOGENUM CEVUMERANUM(INN)