AZINTUXIZUMABUM VEDOTINUM

Látka

AZINTUXIZUMAB VEDOTIN

Informace o látce

INN název: AZINTUXIZUMABUM VEDOTINUM
Český název: AZINTUXIZUMAB VEDOTIN
Anglický název: AZINTUXIZUMAB VEDOTIN
Kód látky: 21308

Synonyma

CAS 1826819-58-2(CA)AZINTUXIZUMAB VEDOTIN(INNE)AZINTUXIZUMAB VEDOTIN(INNC)IMMUNOGLOBULIN G1-KAPPA, ANTI-[HOMO SAPIENS SLAMF7 (SLAM FAMILY MEMBER 7, CD2 SUBSET 1, CS1, CD2-LIKE RECEPTOR-ACTIVATING CYTOTOXIC CELLS, CRACC, 19A24, CD319)], HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY ANTIBODY CONJUGATED TO AURISTATIN E; GAMMA1 HEAVY CHAIN (1-447) [HUMANIZED VH (HOMO SAPIENS IGHV3-7*01(91.80%) -(IGHD) -IGHJ4*01 L123>T (112)) [8.8.10] (1-117) -HOMO SAPIENS IGHG1*03V, G1M3>G1M17, NG1M1 (CH1 R120>K (214) (118-215), HINGE (216-230), CH2 (231-340), CH3 E12(366), M14 (368) (341-445), CHS (446-447) (118-447)], (220-220')- DISULFIDE WITH KAPPA LIGHT CHAIN CHIMERIC (1'-220') [MUS MUSCULUS V-KAPPA (IGKV1-110*01 (93.00%) -IGKJ4*01) [11.3.10] (1'-113') -HOMO SAPIENS IGKC*01, KM3 A45.1 (159), V101 (197) (114'-220')]; DIMER (226-226'':229-229'')- BISDISULFIDE; CONJUGATED, ON AN AVERAGE OF 3 CYSTEINYL, TO MONOMETHYLAURISTATIN E (MMAE), VIA A CLEAVABLE MALEIMIDOCAPROYL-VALYL-CITRULLINYL-PAMINOBENZYLOXYCARBONYL (MC-VAL-CIT-PABC) TYPE LINKER, RECOMMENDED INN: LIST 78

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