(INND)
BEMDANEPROCEL(INNC)
ALLOGENIC DOPAMINERGIC NEURAL PROGENITOR CELLS DERIVED FROM THE WA09 HUMAN EMBRYONIC STEM CELL (HESC) WORKING CELL BANK (WCB). THE CELLS ARE EXPANDED AND DIFFERENTIATED ON PLATES COATED WITH A BASEMENT MEMBRANE EXTRACT. CELLS ARE INITIALLY GROWN IN A XENO-FREE AND FEEDER-FREE MEDIUM SUPPLEMENTED WITH A RHO-ASSOCIATED PROTEIN KINASE (ROCK) INHIBITOR. THE CELLS ARE THEN REPLATED INTO POLYORNITHINE, LAMININ, AND FIBRONECTIN COATED FLASKS TO UNDERGO MULTIPLE MATURATION/DIFFERENTIATION STEPS IN NEUROBASAL MEDIA CONTAINING: BONE MORPHOGENETIC PROTEIN (BMP) INHIBITOR, ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITOR, SONIC HEDGEHOG, GLYCOGEN SYNTHASE KINASE (GSK) 3 INHIBITOR, BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF), GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF), CAMP, TRANSFORMING GROWTH FACTOR BETA-3 (TGFB3), ... PROPOSED INN: LIST 127(WHO)
BEMDANEPROCELUM(INN)