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CEMACABTAGEN ANSEGEDLEUCEL
CEMACABTAGÉN ANSEGEDLEUCEL
CÉMACABTAGENE ANSÉGEDLEUCEL
ALLOGENEIC T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS OF HEALTHY VOLUNTEER DONORS, TRANSDUCED WITH A SELF-INACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING HUMAN CD19. THE CELLS ARE ALSO GENETICALLY MODIFIED USING TRANSCRIPTION ACTIVATOR-LIKE (TAL) EFFECTOR NUCLEASES THAT ARE TRANSIENTLY DELIVERED INTO THE CELL AS MRNAS VIA ELECTROPORATION AND CODE FOR TWO PAIRS: ONE PAIR IS DESIGNED FOR DISRUPTION OF THE T-CELL RECEPTOR ALPHA CONSTANT (TRAC) AND THE OTHER FOR DISRUPTION OF THE CD52 LOCUS...CORRECTED WHO CHEMICAL NAME: RECOMMENDED LIST 93