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AUTOLOGOUS T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC) BY LEUKAPHERESIS, TRANSDUCED WITH A SELF-INACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING THE B-CELL MATURATION ANTIGEN (BCMA). THE EXPRESSED TRANSGENE COMPRISES AN IGGKAPPA CHAIN V-III LEADER SEQUENCE, A HUMANIZED ANTI-BCMA SINGLE CHAIN VARIABLE FRAGMENT (SCFV, CLONE J22.9), A CD8ALPHA HINGE AND TRANSMEMBRANE DOMAIN, AND A 4-1BB CO-STIMULATORY DOMAIN AND CD3ZETA SIGNALLING DOMAIN, UNDER CONTROL OF THE HUMAN ELONGATION FACTOR 1 ALPHA (EF-1ALPHA) PROMOTER. THE CONSTRUCT IS FLANKED BY 5' AND 3' LONG TERMINAL REPEATS (LTRS) AND ALSO CONTAINS A PSI PACKAGING SIGNAL, A REV RESPONSE ELEMENT (RRE), A CENTRAL POLYPURINE TRACT (CPPT) SEQUENCE AND A WOODCHUCK HEPATITIS VIRUS POSTTRANSCRIPTIONAL REGULATORY ELEMENT (WPRE). THE VECTOR IS PSEUDOTYPED WITH THE VESICULAR STOMATITIS VIRUS (VSV) G ENVELOPE PROTEIN...PROPOSED INN: LIST 130