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HUMAN CULTURE EXPANDED ACTIVATED AUTOLOGOUS TUMOURINFILTRATING LYMPHOCYTES (TIL) ISOLATED FROM CERVICAL CANCER TISSUE. THE CELLS ARE MECHANICALLY AND ENZYMATICALLY ISOLATED FROM RESECTED TUMOUR BIOPSY OF PATIENTS AND CULTURED IN SERUM-FREE MEDIA CONTAINING RECOMBINANT INTERLEUKIN 2 (IL-2). THE CELLS ARE ACTIVATED IN SERUM-FREE MEDIA USING ANTI-CD3 ANTIBODY, IL-2 AND THEN FURTHER EXPANDED IN THE PRESENCE OF IRRADIATED ALLOGENEIC PERIPHERAL-BLOOD MONONUCLEAR CELLS (PBMCS) DERIVED FROM HEALTHY DONORS. THE T LYMPHOCYTES (>90% CD45+CD3+) ARE A HETEROGENEOUS MIXTURE OF CD4+ AND CD8+ TILS PREDOMINANTLY WITH EFFECTOR MEMORY, CENTRAL MEMORY AND EFFECTOR CELL SUBSETS, AND A LOW LEVEL OF CD45+CD3-CD56+ NATURAL KILLER (NK) CELLS (0-10%). THE T-LYMPHOCYTES DEMONSTRATE CYTOLYTIC ACTIVITY AND SECRETE CYTOKINES IN A CO-CULTURE-BASED ASSAY