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CRETOSTIMOGEN GRENADENOREPVEC
CRETOSTIMOGÉN GRENADENOREPVEC
CRÉTOSTIMOGENE GRENADÉNOREPVEC
RECOMBINANT CONDITIONALLY REPLICATION-COMPETENT ONCOLYTIC ADENOVIRUS TYPE 5 (AD5) IN WHICH THE ENDOGENOUS E1A PROMOTER HAS BEEN REPLACED WITH THE HUMAN E2F-1 PROMOTER (ALSO KNOWN AS RETINOBLASTOMA-ASSOCIATED PROTEIN 1), WITH THE E3 19 KDA GLYCOPROTEIN (GP19KD)-CODING REGION REPLACED WITH A HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) CDNA SEQUENCE, AND WITH A SIMIAN VIRUS 40 (SV40) LATE POLYADENYLATION SIGNAL INSERTED UPSTREAM OF THE E2F-1 PROMOTER.