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FCX-007
DABOCEMAGÉN AUTOFICEL
DABOCÉMAGENE AUTOFICEL
AUTOLOGOUS HUMAN DERMAL FIBROBLAST CELLS DERIVED FROM SKIN BIOPSIES, AND TRANSDUCED WITH A NON-REPLICATING, SELF-INACTIVATING LENTIVIRUS VECTOR THAT ENCODES HUMAN COLLAGEN TYPE VII ALPHA 1 (COL7A1) UNDER THE CONTROL OF A HUMAN CYTOMEGALOVIRUS (CMV) PROMOTER / 5' UTR REGION WITH KOZAK SEQUENCE; THE CONSTRUCTIS FLANKED BY 5' AND 3' LONG TERMINAL REPEATS (LTR) AND ALSO CONTAINS A HUMAN IMMUNODEFICIENCY VIRUS (HIV) REV RESPONSE ELEMENT (RRE) AND HIV CENTRAL POLYPURINE TRACT (CPPT) SEQUENCES. THE VECTOR IS PSEUDOTYPED WITH THE ENVELOPE GLYCOPROTEIN (G) OF VESICULAR STOMATITIS VIRUS (VSV)...; PROPOSED INN: LIST 125, RECOMMENDED INN: LIST 87