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DÉBAMESTROCEL
AUTOLOGOUS BONE MARROW-DERIVED MESENCHYMAL STROMAL CELLS (MSC) DIFFERENTIATED TO SECRETE HIGH LEVELS OF NEUROTROPHIC FACTORS (NTF). THE MSCS ARE ISOLATED FROM THE BONE MARROW ASPIRATE AND CULTURED IN XENO-FREE GROWTH MEDIUM CONTAINING 10% PLATELET LYSATE. TO INDUCE MSC DIFFERENTIATION, THE CELLS ARE CULTURED IN SERUM-FREE MEDIA SUPPLEMENTED WITH DIBUTYRYL CYCLIC AMP (DBCAMP), HUMAN BASIC FIBROBLAST GROWTH FACTOR (BFGF), HUMAN PLATELET DERIVED GROWTH FACTOR (PDGF-AA), AND HUMAN HEREGULIN-BETA1. THE CELLS EXPRESS MESENCHYMAL PROGENITOR CELL MARKER CLUSTER OF DIFFERENTIATION 73 (CD73), CD90, AND CD105 (>90%) AND SECRETE HIGH LEVELS OF NTF (GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF), BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF), VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND HEPATOCYTE GROWTH FACTOR (HGF)), HAVING VEGF (MORE OR EQUAL TO 7000 PG/10^6 CELLS) AS THE MOST REPRESENTATIVE