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DORUXAPAPOGÉN RALAPLÁSMIDO
DORUXAPAPOGENE RALAPLASMIDE
DNA PLASMID ENCODING A FUSION PROTEIN CONSISTING OF E6 AND E7 PROTEINS FROM HUMAN PAPILLOMA VIRUS (HPV) TYPES 11 AND 6, WITH EACH PROTEIN CODING SEQUENCE SEPARATED BY A FURIN P2A CLEAVAGE SITE IN THE ORDER HPV11 E6/FURIN PEPTIDE/HPV11 E7/FURIN PEPTIDE/HPV6 E6/FURIN PEPTIDE/HPV6 E7, HAVING AN N-TERMINAL IMMUNOGLOBULIN E (IGE) LEADER SEQUENCE, DRIVEN BY A HUMAN CYTOMEGALOVIRUS (CMV) IMMEDIATE-EARLY PROMOTER AND TERMINATED BY THE BOVINE GROWTH HORMONE POLYADENYLATION SIGNAL (BGH POLYA). THE PLASMID ALSO CONTAINS A PUC ORIGIN OF REPLICATION AND A KANAMYCIN RESISTANCE GENE