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EFOCIPEGTRUTIDA
ÉFOCIPÉGTRUTIDE
CHIMERIC TRIPLE RECEPTOR AGONIST PEPTIDE (1''-40''), SHARING BALANCED SEQUENCE HOMOLOGY WITH GLUCAGON, GLUCAGON-LIKE PEPTIDE 1 (GLP1) AND GASTRIC INHIBITORY POLYPEPTIDE (GIP, GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE, INCRETIN HORMONE), PRODUCED BY CHEMICAL SYNTHESIS, CONJUGATED AT THE S ATOM OF THE C-TERMINAL CYSTEINAMIDE 40'' VIA A POLYETHYLENE GLYCOL LINKER (~10 KDA) TO THE N ATOM OF ONE N-TERMINAL PROLINE RESIDUE OF THE DIMER (3-3')-DISULFIDE OF AN IMMUNOGLOBULIN G4 (IGG4) HEAVY CHAIN CONSTANT FRAGMENT (FC, C-TERMINAL 221-PEPTIDE, PRODUCED IN ESCHERICHIA COLI, NOT GLYCOSYLATED):...; PROPOSED INN: LIST 126