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ENEKINRAGEN INZADENOVEC
ENEKINRAGÉN INZADENOVEC
ÉNÉKINRAGENE INZADÉNOVEC
RECOMBINANT, NON-REPLICATING ADENOVIRUS TYPE 5 (AD5) VECTOR ENCODING CODON-OPTIMISED HUMAN INTERLEUKIN 1 RECEPTOR ANTAGONIST (IL-1RA) UNDER THE CONTROL OF AN ENGINEERED NUCLEAR FACTOR KAPPA B (NF-KAPPAB) INDUCIBLE PROMOTER COMPOSED OF FIVE CONSERVED NF-KAPPAB BINDING MOTIF REPEATS FUSED TO A PROXIMAL PROMOTER REGION OF THE HUMAN ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE (ELAM) GENE (NF-KAPPAB5-ELAM), AND TERMINATED BY A SIMIAN VIRUS 40 (SV40) POLYADENYLATION SEQUENCE. THE VECTOR GENOME IS FLANKED BY HUMAN AD5 INVERTED TERMINAL REPEATS (ITRS) AND THE BULK OF THE ADENOVIRUS GENOME HAS BEEN REPLACED BY A NON-CODING HUMAN HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (HPRT) STUFFER SEQUENCE AND BY A HUMAN NON-CODING COSMID INSERT CONTAINING THE POLYMORPHIC MARKER DXS455