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ENSOMAFUSP ALFA
ENSOMAFUSPUM ALFA
HUMANIZED IMMUNOGLOBULIN G1-KAPPA ANTI-(HUMAN B-LYMPHOCYTE ANTIGEN CD19) MODIFIED HETERODIMER WHERE THE HEAVY AND LIGHT CHAIN VARIABLE REGIONS OF ONE ARM HAVE BEEN SUBSTITUTED BY THREE SUBUNITS OF HUMAN 4-1BB LIGAND (TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 9, TNFSF9) WITH THE FOLLOWING STRUCTURAL ARRANGEMENT: HUMAN 4-1BB LIGAND FRAGMENT (71-248, 1-178 IN THE CURRENT SEQUENCE) FUSED VIA PEPTIDYL LINKER ^179GGGGSGGGGS^188 TO HUMAN 4-1BB LIGAND FRAGMENT (71-248, 189-366 IN THE CURRENT SEQUENCE), FUSED VIA PEPTIDYL LINKER ^367GGGGSGGGGS^376 TO IMMUNOGLOBULIN G1 KAPPA LIGHT CHAIN CONSTANT REGION (377-483) VARIANT (E^392>R, Q^393>K), WHICH IS LINKED TO IMMUNOGLOBULIN G1 HEAVY CHAIN...; PROPOSED INN: LIST 125