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EQUECABTAGEN AUTOLEUCEL
EQUECABTAGÉN AUTOLEUCEL
ÉQUÉCABTAGENE AUTOLEUCEL
AUTOLOGOUS T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS, TRANSDUCED WITH A SELF-INACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING HUMAN B CELL MATURATION ANTIGEN (BCMA). THE EXPRESSED TRANSGENE COMPRISES A CD8ALPHA LEADER SEQUENCE, AN ANTI-BCMA SINGLE CHAIN VARIABLE FRAGMENT (SCFV), A CD8ALPHA HINGE AND TRANSMEMBRANE DOMAIN, AND A 4-1BB (CD137) AND CD3ZETA SIGNAL DOMAIN, UNDER CONTROL OF THE HUMAN ELONGATION FACTOR 1 ALPHA (EF-1ALPHA) PROMOTER. THE CONSTRUCT IS FLANKED BY 5' AND 3' LONG TERMINAL REPEATS (LTRS) AND ALSO CONTAINS A PSI PACKAGING SIGNAL, A REV RESPONSE ELEMENT (RRE), A CENTRAL POLYPURINE TRACT (CPPT) SEQUENCE AND AN OPTIMIZED WOODCHUCK HEPATITIS VIRUS POSTTRANSCRIPTIONAL REGULATORY ELEMENT (WPRE). THE VECTOR IS PSEUDOTYPED WITH VESICULAR STOMATITIS VIRUS (VSV) GLYCOPROTEIN G; ... PROPOSED INN: LIST 127.