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ESONADOGEN IMVOPARVOVEC
ESONADOGÉN IMVOPARVOVEC
ÉSONADOGENE IMVOPARVOVEC
RECOMBINANT, NON-REPLICATING ADENO-ASSOCIATED VIRUS SEROTYPE 2 (AAV2) VECTOR ENCODING CODON-OPTIMISED HUMAN NADH DEHYDROGENASE SUBUNIT 4 (ALSO KNOWN AS NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; MTND4, NADH4, ND4) PRECEDED BY A KOZAK SEQUENCE AND A MITOCHONDRIAL TARGETING SEQUENCE FROM HUMAN HEME A: FARNESYLTRANSFERASE CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ALSO KNOWN AS PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL; GENE COX10), UNDER CONTROL OF A HUMAN CYTOMEGALOVIRUS ENHANCER/PROMOTER PLUS A MACACINE HERPESVIRUS-3 CHIMERIC INTRON, FOLLOWED WITH A COX10 GENE 3'- UNTRANSLATED REGION (UTR), AND TERMINATED BY A SIMIAN VIRUS 40 (SV40) POLYADENYLATION SIGNAL, AND FLANKED BY AAV2 INVERTED TERMINAL REPEATS (ITRS)