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ÉVENCALEUCEL
AUTOLOGOUS LYMPHOCYTES ENRICHED IN ACTIVATED NATURAL KILLER CELLS (NK), DERIVED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS). THE CELLS ARE CULTURED IN MEDIUM SUPPLEMENTED WITH HUMAN SERUM AND INTERLEUKIN 2 (IL-2), AND ACTIVATED BY ADDITION OF THE ANTI-CD3 ANTIBODY MUROMONAB-CD3. AT LEAST 10% OF THE CELLS ARE NK CELLS (CD3-CD56+), BUT THE SUBSTANCE ALSO CONTAINS T CELLS (CD3+CD56-) AND NK-LIKE T CELLS (CD3+CD56+). AT LEAST 30% OF THE NK CELLS SHOW CYTOTOXIC ACTIVITY AND RESPOND IN A FUNCTIONAL TEST AGAINST THE LEUKEMIA CELL LINE K562 WITH SURFACE EXPRESSION OF LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1 (LAMP-1, CD107A)