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ÉVRULEUCEL
ALLOGENEIC CYTOTOXIC T LYMPHOCYTES (CTLS) SPECIFIC FOR EPSTEIN-BARR VIRUS (EBV) LATENCY PROTEINS, INCLUDING LATENT MEMBRANE PROTEIN 1 (LMP1), LMP2, AND EBV NUCLEAR ANTIGEN 1 (EBNA1). PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) ISOLATED BY APHERESIS FROM HEALTHY EBV-SEROPOSITIVE DONORS ARE STORED ACCORDING TO HUMAN LEUKOCYTE ANTIGEN (HLA) TYPING. THE PBMCS ARE THEN CO-CULTURED IN MEDIA CONTAINING INTERLEUKIN 2 (IL-2) TOGETHER WITH IRRADIATED ANTIGEN-PRESENTING CELLS, CREATED BY INCUBATION OF PBMCS FROM THE SAME DONOR WITH A REPLICATIONDEFICIENT ADENOVIRUS ENCODING A TRANSGENE THAT EXPRESSES A TRUNCATED EBNA1 PROTEIN FUSED TO A POLYPEPTIDE CONTAINING MULTIPLE EPITOPES FROM LMP1 AND LMP2. THE FINAL CELL POPULATION CONSISTS OF >70% CD3+ T LYMPHOCYTES (MIX OF CD4+/CD8+ T LYMPHOCYTES), WITH THE REMAINING CELLS MADE UP OF NATURAL KILLER (NK) CELLS, B LYMPHOCYTES, AND MONOCYTES (TYPICALLY <1%). ... PROPOSED INN: LIST 129, RECOMMENDED INN: LIST 91