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ALLOGENEIC MEMORY-LIKE NATURAL KILLER (NK) CELLS DERIVED AFTER CYTOKINE INDUCTION FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OF HLA-HAPLOIDENTICAL DONORS. THE PBMCS ARE DEPLETED OF CD3+ CELLS AND CULTURED IN MEDIA CONTAINING INTERLEUKIN 15 AND 21 (IL-15, IL-21), HYDROCORTISONE AND FETAL BOVINE SERUM (FBS) TO INDUCE TRANS-DIFFERENTIATION. THE FINAL CELL POPULATION CONSISTS OF NK CELLS (CD3-CD56+ >80%), EXPRESSING CD122 (>80%) AND DOES NOT CONTAIN CD3+ CELLS (<5%). THE CELLS CAN PRODUCE PERFORIN 1 AND GRANZYME AND DEMONSTRATE CYTOTOXICITY AGAINST MYELOGENOUS LEUKEMIA CELLS IN VITRO (MORE OR EQUAL TO 50%)