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IGRELIMOGEN LITADENOREPVEC
IGRELIMOGÉN LITADENOREPVEC
IGRÉLIMOGENE LITADÉNOREPVEC
RECOMBINANT, REPLICATION-COMPETENT ONCOLYTIC ADENOVIRUS TYPE 5 (AD5) VECTOR ENCODING HUMAN TUMOUR NECROSIS FACTOR ALPHA (TNFALPHA) AND HUMAN INTERLEUKIN 2 (IL-2) SEPARATED BY AN INTERNAL RIBOSOMAL ENTRY SITE (IRES), INSERTED INTO THE E3 REGION DELETED FOR GP19K/6.7K, AND UNDER CONTROL OF THE VIRAL E3 PROMOTER. VIRAL REPLICATION IS UNDER CONTROL OF A TUMOURSELECTIVE E2F PROMOTER THAT IS LINKED TO A 24-BP DELETION IN THE ADENOVIRAL E1A REGION. THE GENE ENCODING THE VIRAL FIBER PROTEIN IS A CHIMERA WITH AN ADENOVIRUS (AD) TYPE 3 KNOB SEQUENCE AND AN AD TYPE 5 SHAFT AND TAIL SEQUENCE.