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ALLOGENIC NATURAL KILLER (NK) CELLS (CD56+CD3-) DERIVED FROM CORD BLOOD CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS (HSPCS). THE CD34+ HSPC SELECTED FRACTION IS COLLECTED IN GROWTH MEDIUM CONTAINING STEM CELL FACTOR (SCF), THROMBOPOIETIN (TPO), FMS-LIKE TYROSINE KINASE 3 LIGAND (FLT3L) AND INTERLEUKIN 7 (IL-7). CD34+ HSPC EXPANSION AND SUBSEQUENT HSPC-NK CELL DIFFERENTIATION TAKES PLACE IN GROWTH MEDIUM CONTAINING SCF, IL-7, IL-2 AND IL-15. THE CELLS EXPRESS (>30%) THE ACTIVATING RECEPTORS NK CELL RECEPTOR D (NKG2D), DNAM-1 (CD226 ANTIGEN), NKP44, AND THE INHIBITORY RECEPTOR NKG2A AND SHOW VERY LOW KILLER-CELL IMMUNOGLOBULIN-LIKE RECEPTOR (KIR) EXPRESSION. THE CELLS CONTAIN AND RELEASE PERFORIN, GRANZYME B AND INTERFERON GAMMA (IFN-GAMMA), AND EXERT CYTOTOXICITY AGAINST MULTIPLE MHC CLASS I POSITIVE AND NEGATIVE TUMOUR CELL LINES.