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ALLOGENEIC HUMAN MULTIPOTENT ADULT PROGENITOR CELLS (MAPC) DERIVED FROM BONE MARROW AND ISOLATED BY DENSITY GRADIENT CENTRIFUGATION. THE CELLS ARE EXPANDED EX VIVO ON FIBRONECTIN-COATED SURFACES UNDER LOWOXYGEN CONDITIONS AND IN THE PRESENCE OF GROWTH MEDIA FOR THE CREATION OF A MASTER CELL BANK (PASSAGE 4), A WORKING CELL BANK (PASSAGE 6) AND ACTIVE SUBSTANCE (PASSAGE 9). THE CELLS ARE ADHERENT, SECRETE PROANGIOGENIC FACTORS (INCLUDING VEGF, IL-8 AND CXCL5) AND OF MESENCHYMAL PROGENITOR LINEAGE (IN VITRO DIFFERENTIATION TO ENDOTHELIAL, HEPATIC AND NEURONAL LINEAGES). THE CELLS EXPRESS CD49C AND CD90 (MORE OR EQUAL TO 95% OF THE CELLS), AND LACK EXPRESSION OF CD45 AND HLA II (<5%). ADDITIONAL MARKERS INCLUDE >90% CD13, CD44, CD73, CD105 AND <5% CD34. THE CELLS HAVE ALSO BEEN SHOWN TO INDUCE T CELL SUPPRESSION; PROPOSED INN: LIST 123, REC. LIST 85