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IXOBEROGEN SOROPARVOVEC
IXOBEROGÉN SOROPARVOVEC
RECOMBINANT, NON-REPLICATING ADENO-ASSOCIATED VIRUS SEROTYPE 2 (AAV2) VECTOR, WITH A MUTATED VARIANT OF CAPSID PROTEIN VP1 (AAV2.7M8), ENCODING A CODONOPTIMISED FUSION PROTEIN THAT CONSISTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)-BINDING PORTIONS FROM THE EXTRACELLULAR DOMAINS OF HUMAN VEGF RECEPTORS 1 AND 2 FUSED TO THE FC PORTION OF HUMAN IGG1, UNDER CONTROL OF A HUMAN CYTOMEGALOVIRUS PROMOTER, PRECEDED BY AN ADENOVIRUS TRIPARTITE LEADER SEQUENCE, SYNTHETIC INTRON AND KOZAK SEQUENCE, FOLLOWED BY A SCAFFOLD ATTACHMENT REGION (SAR), AND TERMINATED BY A HUMAN GROWTH HORMONE (HGH) POLYADENYLATION SEQUENCE, FLANKED BY AAV2 INVERTED TERMINAL REPEATS (ITRS). THE MATURE EXPRESSED PROTEIN IS EQUIVALENT TO AFLIBERCEPT (96)(57).