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LARNEFPENDEKINA ALFA
LARNEFPENDÉKINE ALFA
HUMAN INTERLEUKIN-15 (IL-15) FUSED VIA A PEPTIDE LINKER TO HUMAN IMMUNOGLOBULIN G1 CONSTANT HEAVY CHAIN, DISULFIDE-BRIDGED TO HUMAN IMMUNOGLOBULIN KAPPA CONSTANT LIGHT CHAIN FUSED VIA A PEPTIDE LINKER TO HUMAN INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA (IL-15R-ALPHA, IL-15RA, CD215); HUMAN INTERLEUKIN-15 (IL-15) (1-114, 2-115 IN THE CURRENT SEQUENCE, D1>ADDED, VARIANT (N72>D73) FUSED VIA PEPTIDE LINKER 116AGGKPGGSAGG126 TO GAMMA 1 HEAVY CHAIN (127-454) [HOMO SAPIENS IGHG1*08 (CH1 (127-224), HINGE (225-239), CH2 L243>A, L244>A (240-349), CH3 (350-454), CHS G455>DEL, K456>DEL)], (229- 216')-DISULFIDE WITH KAPPA LIGHT CHAIN (110'-216') [HOMO SAPIENS IGKC*01] FUSED VIA PEPTIDE LINKER 104'GAEGGG109' TO HUMAN INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA (IL-15R-ALPHA, IL-15RA, CD215) (1'-103', VARIANT I1'>D), DIMER (235-235'':238-238'')- BISDISULFIDE, PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, CELL LINE CHO-S, GLYCOFORM ALFA