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LASMECABTAGÉN TIMGEDLEUCEL
LASMÉCABTAGENE TIMGEDLEUCEL
ALLOGENEIC T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS OF HEALTHY DONORS, TRANSDUCED WITH A SELFINACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR ENCODING A DEPLETION LIGAND AND A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD22. THE CELLS ARE ALSO GENETICALLY MODIFIED USING TRANSCRIPTION ACTIVATOR-LIKE (TAL) EFFECTOR NUCLEASES, WHICH ARE TRANSIENTLY DELIVERED INTO THE CELL AS MRNAS TO DISRUPT THE T CELL RECEPTOR ALPHA CONSTANT (TRAC) AND CD52 GENES. ... PROPOSED INN: LIST 131, RECOMMENDED INN: LIST 93