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LETETRESGÉN AUTOLEUCEL
AUTOLOGOUS CD4+ AND CD8+ T CELLS, TRANSDUCED WITH A NONREPLICATING HUMAN IMMUNODEFICIENCY VIRUS (HIV)-DERIVED SELFINACTIVATING (SIN) VECTOR THAT COMPRISES A 5' LTR (RSV*-R-U5) AND A 3' U3 DELETED LTR (U5-R-HIV-1DELTA 3'LTR), ENCODING AN AFFINITY ENHANCED NY-ESO-1 (AUTOIMMUNOGENIC CANCER/TESTIS ANTIGEN NY-ESO-1, CTAG1A, L ANTIGEN FAMILY MEMBER 2, LAGE- 2) SPECIFIC T CELL RECEPTOR (TCR), UNDER THE CONTROL OF ELONGATION FACTOR 1 ALPHA (EF1A) PROMOTER. THE VECTOR IS PSEUDOTYPED WITH VESICULAR STOMATITIS VIRUS GLYCOPROTEIN-G (VSV-G). * RSV: ROUS SARCOMA VIRUS; REC. INN LIST 83