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RECOMBINANT ONCOLYTIC HERPES SIMPLEX VIRUS TYPE 1 (HSV-1) F STRAIN IN WHICH BOTH COPIES OF THE VIRAL GAMMA 1 34.5 GENE (GAMMA134.5, INFECTED CELL PROTEIN 34.5 [ICP34.5]) PLUS THE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT UL39 (ICP6 GENE) LOCUS HAVE BEEN PARTIALLY DELETED/INACTIVATED AND IN WHICH A TRUNCATED COPY OF THE GAMMA134.5 GENE HAS BEEN RE-INSERTED INTO THE GENOME IN THE REGION OF THE UL39 (ICP6) DELETION IN REVERSE COMPLEMENTARY ORIENTATION, UNDER TRANSCRIPTION CONTROL OF A GLIOMA-SELECTIVE MURINE (RATTUS NORVEGICUS) NESTIN ENHANCER AND A MURINE (MUS MUSCULUS) HEAT-SHOCK PROTEIN 68 (HSP68) MINIMUM GENE PROMOTER