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LUTADENOVEC AUTOGÉN
LUTADÉNOVEC AUTOGENE
REPLICATION-DEFECTIVE CHIMPANZEE ADENOVIRUS 68 (CHAD68), SUBGROUP E ADENOVIRUS, (C68, 68/SADV-25, ORIGINALLY DESIGNATED AS PAN 9) VECTOR, WITH E1, E3 AND E4 (PARTIALLY) DELETED, ENCODING A PATIENTSPECIFIC EXPRESSION CASSETTE COMPRISING 20 TUMOUR-SPECIFIC NEOANTIGENS (TSNA). THE EXPRESSION CASSETTE, INTRODUCED INTO THE DELETED VIRAL E1 REGION, INCLUDES CODING SEQUENCES FOR METHIONINE, ALANINE AND GLYCINE (MAG), THE 20 TUMOUR-SPECIFIC NEOANTIGENS, A CLASS II HELPER DOMAIN CONSISTING OF TWO UNIVERSAL CD4+ T HELPER LYMPHOCYTE EPITOPES, THE PAN HUMAN LEUKOCYTE ANTIGEN (HLA) DRBINDING EPITOPE (PADRE) AND THE TETANUS TOXOID P2 EPITOPE (AMINO ACID 830-844 OF TETANUS TOXIN TC), EACH LINKED BY GLYCINE AND PROLINE LINKERS (GPGPG). THE EXPRESSION CASSETTE IS UNDER THE CONTROL OF A TETRACYCLINE REPRESSOR (TETR)-REGULATED CYTOMEGALOVIRUS (CMV) PROMOTER AND A SIMIAN VIRUS 40 (SV40) POLYADENYLATION SIGNAL