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LUVOMERÁN
LUVOMÉRAN
MESSENGER RNA (MRNA), 5' CAPPED, ENCODING CODONOPTIMISED HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (HCFTR; CHANNEL CONDUCTANCECONTROLLING ATPASE, CAMP-DEPENDENT CHLORIDE CHANNEL, ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 7), FLANKED BY 5' AND 3' UNTRANSLATED REGIONS BASED ON THE MUS MUSCULUS HISTONE H1.5 GENE AND THE HUMAN HAEMOGLOBIN SUBUNIT ALPHA (HBA1) GENE, FOLLOWED BY A 3' POLYADENYLATION (POLYA) TAIL (CONTAINING A 100- NUCLEOTIDE POLYA SEQUENCE, A 5-NUCLEOTIDE XBAI SCAR AND A 20-NUCLEOTIDE POLYA SEQUENCE ENDING WITH AN INVERTED DT); CONTAINS N^1-METHYLPSEUDOURIDINE INSTEAD OF URIDINE (ALL-U>M^1PSI)