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AUTOLOGOUS DENDRITIC CELLS (DCS) DERIVED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED FROM GLIOBLASTOMA PATIENTS. A SAMPLE OF THE SAME PATIENTS' GLIOBLASTOMA IS ALSO COLLECTED, AND A TUMOUR LYSATE PREPARED. THE PURIFIED ADHERENT MONOCYTES ISOLATED FROM PBMCS ARE INITIALLY GROWN IN MEDIA CONTAINING GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GMCSF) AND INTERLEUKIN 4 (IL-4) TO INDUCE DIFFERENTIATION INTO DENDRITIC CELLS, FOLLOWED BY LOADING OF THE DENDRITIC CELLS WITH THE TUMOUR LYSATE IN CULTURE MEDIA SUPPLEMENTED WITH GM-CSF AND IL-4. THE FINAL CELL SUSPENSION CONTAINS MORE THAN OR EQUAL TO 60% DENDRITIC CELLS (MHC CLASS II+, CD86+; CD14-), WITH LESS THAN OR EQUAL TO 40% OF THE CELLS IN THE SUSPENSION BEING OTHER AUTOLOGOUS CELLS, SUCH AS T LYMPHOCYTES, B LYMPHOCYTES, AND NATURAL KILLER CELLS. THE DENDRITIC CELLS INDUCE T CELL PROLIFERATION IN A CO-STIMULATION ASSAY