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NALOTIMAGÉN CARMALEUCEL
HUMAN CULTURE EXPANDED ACTIVATED ALLOGENEIC T CELLS FOR ADJUNCTIVE IMMUNOTHERAPY. CELLS ARE DERIVED FROM THE HAEMATOPOIETIC STEM CELL (HSC) DONOR AND ARE GENETICALLY MODIFIED EX VIVO WITH A NON-REPLICATIVE SFCMM-3 GAMMA-RETROVIRAL VECTOR DERIVED FROM MOLONEY MURINE LEUKEMIA VIRUS (MO-MULV), ENCODING FOR A TRUNCATED FORM OF THE HUMAN LOW AFFINITY NERVE GROWTH FACTOR RECEPTOR (DELTA LNGFR) AND THE HERPES SIMPLEX VIRUS THYMIDINE KINASE (HSV-TK MUT2). CELLS CONTAIN A SUICIDE GENE IN CASE OF GRAFT VERSUS HOST DISEASE DEVELOPMENT