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NAVEPEGRITIDA
NAVÉPÉGRITIDE
C231-H386-N64-O67-S5-(C2-H4-O)4X WITH X BEING CCA 220-245
C-TYPE NATRIURETIC PEPTIDE (CNP), HUMAN, (89-126)-FRAGMENT (1-38) (CNP-38), CONJUGATED AT N^6 OF LYS26 WITH FOUR O-METHYLPOLY(ETHYLENE GLYCOL) CHAINS (APPROX. 10 KDA EACH) VIA A CLEAVABLE TETRAANTENNARY LINKER; L-LEUCYL-L-GLUTAMINYL-L-ALPHA-GLUTAMYL-L-HISTIDYL-L-PROLYL-L-ASPARAGINYL-LALANYL-L-ARGINYL-L-LYSYL-L-TYROSYL-L-LYSYLGLYCYL-L-ALANYL-L-ASPARAGINYL-L-LYSYL-L-LYSYLGLYCYL-L-LEUCYL-L-SERYL-L-LYSYLGLYCYL-L-CYSTEINYL-LPHENYLALANYLGLYCYL-L-LEUCYL-N^6-{N^2-[N^2,N^6-BIS(6-{[(3RS)-1-{3-[(3-{(2RS)-2,3-BIS[ALPHA-METHYLPOLY(OXYETHYLENE)-OMEGA-OXY]PROPOXY}PROPYL)AMINO]-3-OXOPROPYL}-2,5-DIOXOPYRROLIDIN-3-YL]SULFANYL}HEXANOYL)-L-LYSYL]-N^2-METHYL-N^1-[2-(METHYLAMINO)ETHYL]-LISOASPARAGINYL}-L-LYSYL-L-LEUCYL-L-ALPHA-ASPARTYL-L-ARGINYL-LISOLEUCYLGLYCYL-L-SERYL-L-METHIONYL-L-SERYLGLYCYL-L-LEUCYLGLYCYL-LCYSTEINE (22-38)-DISULFIDE