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OPILRELAGÉN ATRADENOREPVEC
OPILRÉLAGENE ATRADÉNOREPVEC
RECOMBINANT REPLICATION-COMPETENT ONCOLYTIC ADENOVIRUS TYPE 5 (AD5), WITH THE ORIGINAL PROMOTER OF E1A REPLACED WITH TWO CONSECUTIVE HUMAN TELOMERASE REVERSE TRANSCRIPTASE (TERT) PROMOTERS, WITH E1B- 19KDA INACTIVATED (BY DELETION OF THE START CODON AND THE ADJACENT INSERTION OF A STOP CODON), AND WITH E3 DELETED AND REPLACED WITH THE HUMAN RELAXIN 1 GENE WHOSE EXPRESSION IS UNDER CONTROL OF A CYTOMEGALOVIRUS (CMV) PROMOTER