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PERSICABTAGÉN LEMGEDLEUCEL
ALLOGENEIC CD4+/CD8+ T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS OF HEALTHY DONORS, TRANSDUCED WITH A LENTIVIRAL VECTOR TO OVEREXPRESS CD47 AND A CD19-DIRECTED CHIMERIC ANTIGEN RECEPTOR (CAR). THE CELLS HAVE ALSO BEEN GENE-EDITED USING CRISPR/CAS12B (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/ CRISPRASSOCIATED PROTEIN 12B) THE CELLS HAVE ALSO BEEN GENE-EDITED USING CRISPR/CAS12B (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/CRISPR-ASSOCIATED PROTEIN 12B) NUCLEASE INTRODUCED AS MRNA ... PROPOSED INN: LIST 131, RECOMMENDED INN: LIST 93