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POMLUCABTAGEN AUTOLEUCEL
POMLUCABTAGÉN AUTOLEUCEL
AUTOLOGOUS T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS, TRANSDUCED WITH A SELF-INACTIVATING, NON-REPLICATING MURINE STEM CELL VIRUS (MSCV) VECTOR, ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING HUMAN GANGLIOSIDE GM2. THE EXPRESSED CAR TRANSGENE COMPRISES A LEADER SEQUENCE DERIVED FROM A HUMAN IMMUNOGLOBULIN 452 HEAVY CHAIN, A HUMAN GM2-SPECIFIC SINGLE-CHAIN VARIABLE FRAGMENT (SCFV), A HUMAN CD8 TRANSMEMBRANE DOMAIN, CD28, 4-1BB AND CD3ZETA INTRACELLULAR SIGNAL MOTIF. THE VECTOR GENOME ALSO CONTAINS TRANSGENES ENCODING HUMAN INTERLEUKIN-7 (IL-7), HUMAN C-C MOTIF CHEMOKINE 19 (CCL19) AND HERPES SIMPLEX VIRUSDERIVED THYMIDINE KINASE TRANSGENE (HSV-TK), WITH EACH TRANSGENE SEPARATED BY SEQUENCES ENCODING A FOOT AND MOUTH DISEASE 2A SELF-CLEAVING PEPTIDE; ... PROPOSED INN: LIST 127, RECOMMENDED INN: LIST 89