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PRITEBEGÉN ZEPADENOVEC
PRITÉBÉGENE ZÉPADÉNOVEC
REPLICATION-DEFICIENT CHIMPANZEE ADENOVIRUS VECTOR (CHADOX1-DELTAE1 DELTAE3 E4-MODIFIED), ENCODING A CODON-OPTIMIZED FUSION PROTEIN CONTAINING MULTIPLE HEPATITIS B VIRUS (HBV) ANTIGENS, COMPRISING THE HBV PRE-CORE ANTIGEN, CORE ANTIGEN, A NONFUNCTIONAL POLYMERASE, A C-TERMINAL FRAGMENT OF THE HBV PRE-S1 PROTEIN AND THE PRE-S2 PROTEIN, ALL PRECEDED BY A SHARK INVARIANT (SLI) CHAIN SEQUENCE AND SEPARATED BY A SELF-CLEAVING FOOT-ANDMOUTH VIRUS F2A PEPTIDE SEQUENCE FROM THE LEADER SEQUENCE OF HUMAN TISSUE PLASMINOGEN ACTIVATOR, FOLLOWED BY AN N-TERMINAL FRAGMENT OF THE HBV PRE-S1 PROTEIN AND THE HBV SURFACE ANTIGEN (HBSAG), UNDER CONTROL OF A HUMAN CYTOMEGALOVIRUS (CMV) PROMOTER AND A BOVINE GROWTH HORMONE POLYADENYLATION SIGNAL. THE TRANSGENE IS INSERTED IN THE DELETED E1 REGION OF THE VIRAL VECTOR GENOME