CAS 2163074-26-6(CA)ROVOCTOCOGENE DURPARVOVEC(INNE)ROVOKTOKOGEN DURPARVOVEK(INNC)RECOMBINANT INTRONLESS NON-REPLICATING ADENO-ASSOCIATED VIRUS 2 VECTOR (AAV2) WITH A BIO-ENGINEERED CAPSID DERIVED BY DNA SHUFFLING OF 10 AAV CAPSID SEQUENCES (AAV1, 2, 3B, 4, 5, 6 8, 9, AVIAN AND BOVINE AAV) FOLLOWED BY IN VIVO SELECTION IN FAH^-/-/RAG2^-/-/IL2RG^-/- (FRG) MICE PARTIALLY REPOPULATED WITH HUMAN HEPATOCYTES. THE VECTOR HAS AAV2 GENOMIC INVERTED TERMINAL REPEATS (ITR) AND ENCODES A HUMAN B-DOMAIN-DELETED BLOOD COAGULATION FACTOR VIII (HF8, FACTOR VIII, FVIII) UNDER THE CONTROL OF A MODIFIED TRANSTHYRETIN (TTRM) PROMOTER.