(INNC)
ALLOGENEIC NATURAL KILLER (NK) CELLS DERIVED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC) OBTAINED BY LEUKAPHERESIS FROM HEALTHY DONORS, TRANSDUCED WITH A REPLICATION DEFICIENT MURINE STEM CELL VIRUS (MSCV) DERIVED GAMMA-RETROVIRAL VECTOR ENCODING (I) AN ACTIVATING CHIMERIC RECEPTOR (ACR) COMPOSED OF A CD8ALPHA SIGNAL PEPTIDE, THE EXTRACELLULAR DOMAIN OF THE NATURAL KILLER GROUP 2, MEMBER D (NKG2D) RECEPTOR (ALSO KNOWN AS KILLER CELL LECTIN-LIKE RECEPTOR K1 (KLRK1)), FUSED TO A CD8ALPHA TRANSMEMBRANE DOMAIN, AN OX40 COSTIMULATORY DOMAIN AND A CD3ZETA SIGNALLING DOMAIN, AND (II) INTERLEUKIN-15 (IL-15) PRECEDED BY A CD8ALPHA SIGNAL PEPTIDE AND FUSED TO A CD8ALPHA HINGE AND TRANSMEMBRANE DOMAIN, WHICH CREATES A MEMBRANE BOUND FORM OF IL-15 (MBIL-15), SEPARATED BY A SELF-CLEAVING T2A PEPTIDE. THE VECTOR IS PSEUDOTYPED WITH RD-114 VIRUS ENVELOPE GLYCOPROTEIN. ... PROPOSED INN: LIST 131, RECOMMENDED INN: LIST 93(WHO)
SENACNAGENUM ENFALEUCELUM(INN)