(INNC)
CANINE CULTURE EXPANDED ADIPOSE-DERIVED ALLOGENEIC MESENCHYMAL-LIKE STROMAL CELLS FOR CELL-BASED THERAPY. CELLS EXPRESS CELL SURFACE MARKERS CD44 AND CD90 (THY-1 MEMBRANE GLYCOPROTEIN), AND SECRETE INTERLEUKIN-8 (IL-8), MONOCYTE CHEMOTACTIC PROTEIN 1 (MCP-1, C-C MOTIF CHEMOKINE 2), HEPATOCYTE GROWTH FACTOR (HGF, SCATTER FACTOR, SF, HEPATOPOEITIN A), METALLOPROTEINASE INHIBITOR 2 (TIMP-2), C-X-C MOTIF CHEMOKINE 10 (CXCL10, 10 KDA INTERFERON GAMMAINDUCED PROTEIN, IP-10), INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN (IL-1RN , IL-1RA) AND INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO-1, IDO). THE CELLS ARE NEGATIVE FOR CD34, CD45 AND FOR THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS II MARKERS(WHO)
SETAMEVETCELUM(INN)