(INND)
SITOKABNAGEN LOXIVELEUCEL(INNC)
ALLOGENEIC NATURAL KILLER (NK) CELLS DERIVED FROM UMBILICAL CORD BLOOD, TRANSDUCED WITH A MOLONEY MURINE LEUKAEMIA VIRUS (MMLV)-BASED RETROVIRAL VECTOR ENCODING INDUCIBLE CASPASE-9 COMPRISING HUMAN CASPASE-9 FUSED TO A HUMAN FK506 BINDING PROTEIN VARIANT (FKBP-F36V), A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19 FUSED TO CD28 AND CD3 ZETA SIGNALLING DOMAINS, AND SECRETABLE HUMAN INTERLEUKIN 15 (IL-15), LINKED TOGETHER BY T2A AND E2A SELFCLEAVING PEPTIDE SEQUENCES, RESPECTIVELY, UNDER THE CONTROL OF THE 5' LONG TERMINAL REPEAT (LTR) MMLV PROMOTER; THE CONSTRUCT IS FLANKED BY 5' AND 3' LTRS AND CONTAINS AN MMLV PSI PACKAGING SIGNAL AND PARTIAL POL GENE. THE VECTOR IS PSEUDOTYPED WITH THE ENVELOPE GLYCOPROTEIN OF GIBBON APE LEUKAEMIA VIRUS (GALV)...; PROPOSED INN: LIST 125, RECOMMENDED INN: LIST 87(WHO)
SITOCABNAGENUM LOXIVELEUCELUM(INN)