(INND)
SOLIZMESTROCEL(INNC)
ALLOGENEIC MESENCHYMAL STROMAL CELLS (MSC) DERIVED FROM GENETICALLY SELECTED UMBILICAL CORD TISSUE. THE CORD TISSUE IS ENZYMATICALLY DIGESTED, AND THE CELLS CULTURED IN A XENO-FREE MEDIUM SUPPLEMENTED WITH HUMAN PLATELET LYSATE. THE CELLS ARE POSITIVE (>90%) FOR THE MESENCHYMAL STROMAL CELL SURFACE MARKERS CD105+, CD73+, CD90+, AND ARE NEGATIVE (<10%) FOR CD45-, CD34-, CD19-, CD11B-, AND HLA-DR-. THE CELLS RELEASE ANTI-FIBROTIC MOLECULES SUCH AS MATRIX METALLOPROTEINASE-1 (MMP-1) AND MICRORNA-29C (MIR-29C). THE CELLS ALSO INHIBIT T LYMPHOCYTE PROLIFERATION UPON CD3/CD28/CD2 ACTIVATION, SUPPRESS TUMOR NECROSIS FACTOR ALPHA (TNFALPHA) SECRETION OF IMMUNE CELLS (PERIPHERAL BLOOD MONONUCLEAR CELLS /MACROPHAGES) UPON LIPOPOLYSACCHARIDES (LPS) STIMULATION, AND UPREGULATE SOLUBLE TNF RECEPTOR 1 AND 2 SECRETION UPON TNFALPHA/INTERFERON GAMMA (IFN-GAMMA) STIMULATION(WHO)
SOLIZMESTROCELUM(INN)