(CA)
SURATADENOTUREV(INNE)
SURATADENOTUREV(CZ)
A REPLICATION-COMPETENT ADENOVIRUS TYPE 5 IN WHICH THE E1A AND E1B GENES ARE UNDER THE CONTROL OF A HUMAN TELOMERASE REVERSE TRANSCRIPTASE (HTERT) AND IRES, RESPECTIVELY. A RECOMBINANT REPLICATION-COMPETENT ADENOVIRUS TYPE 5 (AD-5) IN WHICH THE E1 GENE, INCLUDING ITS NORMAL TRANSCRIPTIONAL REGULATORY ELEMENT, HAS BEEN DELETED AND REPLACED BY AN EXPRESSION CASSETTE CONTAINING AN HTERT (HUMAN TELOMERASE REVERSE TRANSCRIPTASE) PROMOTER, THE AD E1A GENE, AN IRES (INTERNAL RIBOSOME ENTRY SITE) AND THE AD E1B GENE. E1A EXPRESSION IS CONTROLLED BY THE HTERT PROMOTER; E1B TRANSLATION IS EFFECTED BY THE IRES; REC. LIST 85(WHO)
DNA (RECOMBINANT HUMAN TELOMERASE-SPECIFIC REPLICATION-COMPETENT ONCOLYTIC ADENOVIRUS 5 VECTOR OBP-301)(PCHC)
SURATADENOTUREVUM(INN)