(INNC)
AUTOLOGOUS T LYMPHOCYTES OBTAINED FROM PERIPHERAL BLOOD LYMPHOCYTES BY LEUKAPHERESIS, TRANSDUCED WITH A SELFINACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR ENCODING AN AFFINITYENHANCED CANCER TESTIS ANTIGEN (NY-ESO-1^C259) SPECIFIC T-CELL RECEPTOR (TCR) AND CO-EXPRESSING A DOMINANT-NEGATIVE TRANSFORMING GROWTH FACTOR BETA (TGF-BETA) TYPE II CELL SURFACE RECEPTOR (DNTGF-SSRII; TRUNCATED NON-SIGNALLING TGF-BETARII). THE TCR IS BASED ON LETETRESGENE AUTOLEUCEL AND SPECIFICALLY RECOGNISES A PEPTIDE (SLLMWITQC), WHICH IS SHARED BY THE CANCER ANTIGENS NY-ESO-1 (CTAG1B) AND LAGE-1A (CTAG2) PRESENTED ON HUMAN LEUKOCYTE ANTIGEN HLA-A*02.... PROPOSED INN: LIST 128, RECOMMENDED INN: LIST 90(WHO)
SUVUTRESGENUM AUTOLEUCELUM(INN)