(CZ)
AUTOLOGOUS T CELLS OBTAINED FROM THE PERIPHERAL BLOOD OF PATIENTS, COLLECTED BY LEUKAPHERESIS, MODIFIED BY CRISPR/CAS9 (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/CRISPR-ASSOCIATED PROTEIN 9) MEDIATED GENE EDITING CONSISTING OF TWO GUIDE RNAS (GRNAS) INTRODUCED TRANSIENTLY AS RIBONUCLEOPROTEIN (RNP) COMPLEX, AND A NEOEPITOPE T CELL RECEPTOR (NEO- TCR) GENE CASSETTE ENCODED BY PLASMID DNA TO REPLACE THE ENDOGENOUS T CELL RECEPTOR (TCR) WITH A SINGLE PATIENT-DERIVED TUMOUR-SPECIFIC NEO-TCR PER T CELL, WITH A MAXIMUM OF THREE DIFFERENT NEO-TCRS IN THE FINAL DRUG SUBSTANCE...; PROPOSED INN: LIST 124, RECOMMENDED INN: LIST 86(WHO)
TACATRESGENUM AUTOLEUCELUM(INN)