TAMRINTAMABUM PAMOZIRINUM

Látka

TAMRINTAMAB PAMOZIRIN

TAMRINTAMAB PAMOZIRINE

Informace o látce

INN název: TAMRINTAMABUM PAMOZIRINUM
Český název: TAMRINTAMAB PAMOZIRIN
Anglický název: TAMRINTAMAB PAMOZIRINE
Kód látky: 22186

Synonyma

CAS 2148334-68-1(CA)TAMRINTAMAB PAMOZIRINE(INNE)TAMRINTAMAB PAMOZIRIN(INNC)IMMUNOGLOBULIN G1-KAPPA, ANTI-[HOMO SAPIENS DPEP3 (DIPEPTIDASE 3)], HUMANIZED MONOCLONAL ANTIBODY CONJUGATED TO A PYRROLOBENZODIAZEPINE DIMER (PBD) SC-DR002 AT CYS215' AND CYS215'''; GAMMA1 HEAVY CHAIN HUMANIZED (1-452) [VH (HOMO SAPIENS IGHV1- 69*01 (85.7%) -(IGHD) -IGHJ6*01 (90.9%)) [8.8.16] (1-123) -HOMO SAPIENS IGHG1*01, G1M17,1 (CH1 K120 (220) (124-221), HINGE C5>S (226) (222-236), CH2 (237-346), CH3 D12 (362), L14 (364) (347-451), CHS K>DEL (452)) (124-452)], NON-COVALENTLY ASSOCIATED WITH KAPPA LIGHT CHAIN HUMANIZED (1'-215') [V-KAPPA (HOMO SAPIENS IGKV3D-20*01 (86.50%) -IGKJ2*01 (100.0%)) [7.3.9] (1'-108'),-HOMO SAPIENS IGKC*01 (100%), KM3 A45.1 (154), V101 (192) (109'-215')]; DIMER (232-232'':235- 235'')-BISDISULFIDE; CONJUGATED AT EACH CL C126 (215', 215''') TO A PYRROLOBENZODIAZEPINE DIMER (PBD) SC-DR002 VIA A PROTEASE-CLEAVABLE MALEIMIDE LINKER (LD6.23). PROPOSED INN: LIST 120; REC. INN LIST 82

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