(INNS)
TEGRENMERAN(INND)
TEGRENMERAN(INNC)
MESSENGER RNA (MRNA), 5'-CAPPED, ENCODING THE CODON-OPTIMIZED RECEPTOR BINDING DOMAIN (RBD) OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) SPIKE (S) GLYCOPROTEIN (OMICRON SUB-LINEAGES B.1.1.529.4 (BA.4) AND B.1.1.529.5 (BA.5); BASED UPON GISAID: EPI_ISL_12607996), WITH A CYSTEINE TO SERINE SUBSTITUTION AT RESIDUE 233 (CORRESPONDING TO CYS533 IN THE FULLLENGTH SPIKE GLYCOPROTEIN), EXPRESSED AS A FUSION PROTEIN WITH THE S GLYCOPROTEIN SIGNAL PEPTIDE DERIVED FROM SARS-COV-2 WUHAN-HU 1 STRAIN (GENBANK: MN908947.3), FLANKED BY 5' AND 3' UNTRANSLATED REGIONS (UTRS) DERIVED FROM THE HUMAN BETA-GLOBIN GENE AND A 3' POLYADENYLATION (POLYA) TAIL; CONTAINS 5-METHYLURIDINE INSTEAD OF URIDINE (ALL-U>5-ME-U) AND 5-METHYLCYTIDINE INSTEAD OF CYTIDINE (ALL-C>5-ME-C)(WHO)
TEGRENMERANUM(INN)