(INNF)
TEZEMLIMOGÉN DAXADENOREPVEC(INNS)
TEZEMLIMOGEN DAXADENOREPVEC(INND)
RECOMBINANT CONDITIONALLY REPLICATION-COMPETENT ONCOLYTIC ADENOVIRUS TYPE 5 (AD5) ENCODING HUMAN IMMUNE MODULATORY PROTEIN OX40 LIGAND (OX40L, CD252, TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4) UNDER CONTROL OF THE CYTOMEGALOVIRUS (CMV) IMMEDIATE-EARLY PROMOTER-ENHANCER AND TERMINATED WITH THE BOVINE GROWTH HORMONE (BGH) POLYADENYLATION SEQUENCE. THE OX40L SEQUENCE ALONG WITH THE CMV IMMEDIATE-EARLY PROMOTER AND BGH POLYADENYLATION SIGNAL IS INSERTED INTO THE AD5 E3 REGION, DISPLACING APPROXIMATELY 2.69 KB OF THE E3 REGION. GENETIC MODIFICATION ALSO INCLUDES A 24 BP DELETION IN THE E1A GENE AND A 27 BP INSERTION INTO THE FIBER GENE WHICH INTRODUCES AN RGD (ARG-GLY-ASP) MOTIF.(WHO)
TEZEMLIMOGENUM DAXADENOREPVECUM(INN)